DRUMSTICK MUCILAGE MICROSPHERES FOR CONTROLLED RELE ASE OF LAMIVUDINE: DESIGN, OPTIMIZATION AND IN VITRO EVALUATION
By: Gada, Santosh G
.
Contributor(s): Anandkumar, Y.
Publisher: M P Innovare Academic Sciences Pvt Ltd 2019Edition: Vol.11(4).Description: 60-68p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
International journal of pharmacy and pharmaceutical scienceSummary: Objective:
The objective of this study was to design and evalu
ate controlled release mucoadhesive microspheres of
lamivudine using mucoadhesive
polymers and mucilage.
Methods:
Mucoadhesive microspheres of lamivudine were formul
ated by ionic gelation method. The response surface
methodology was adapted
for optimization of formulation using central compo
site design (CCD) for two factors at three levels e
ach was employed to study the effect of
independent variables, Sodium alginate-drumstick mu
cilage (X
1
) and calcium chloride (CaCl
2
) concentration (X
2
) on dependent variables, namely
drug encapsulation efficiency (DEE) and particle si
ze (PS). Optimized drumstick mucilage mucoadhesive
microspheres of lamivudine were obtained
by using numerical optimization of desirability app
roach. The observed microspheres were coincided wel
l with the predicted values by the
experimental design.
Results:
The microspheres formed were spherical in shape, an
d Particle size (PS) ranged between 681.63-941.57μm
. Drug encapsulation efficiency
(DEE) was ranged between 69.63-94.56 %. The drug re
lease for an optimized formulation was 96.58 %. The
mechanism of drug release from
microspheres followed Korsemeyer’s-Peppas and expon
ential ‘n’ value was greater than 0.45, indicating
the drug release was non-fickian i.e.,
swelling followed by erosion mechanism.
Conclusion:
This work suggests that mucoadhesive microspheres,
an effective drug delivery system for lamivudine, c
an be prepared using
drumstick mucilage in improving the bioavailability
of the drug.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
|---|---|---|---|---|---|---|
Articles Abstract Database
|
School of Pharmacy Archieval Section | Not for loan | 2020910 |
Objective:
The objective of this study was to design and evalu
ate controlled release mucoadhesive microspheres of
lamivudine using mucoadhesive
polymers and mucilage.
Methods:
Mucoadhesive microspheres of lamivudine were formul
ated by ionic gelation method. The response surface
methodology was adapted
for optimization of formulation using central compo
site design (CCD) for two factors at three levels e
ach was employed to study the effect of
independent variables, Sodium alginate-drumstick mu
cilage (X
1
) and calcium chloride (CaCl
2
) concentration (X
2
) on dependent variables, namely
drug encapsulation efficiency (DEE) and particle si
ze (PS). Optimized drumstick mucilage mucoadhesive
microspheres of lamivudine were obtained
by using numerical optimization of desirability app
roach. The observed microspheres were coincided wel
l with the predicted values by the
experimental design.
Results:
The microspheres formed were spherical in shape, an
d Particle size (PS) ranged between 681.63-941.57μm
. Drug encapsulation efficiency
(DEE) was ranged between 69.63-94.56 %. The drug re
lease for an optimized formulation was 96.58 %. The
mechanism of drug release from
microspheres followed Korsemeyer’s-Peppas and expon
ential ‘n’ value was greater than 0.45, indicating
the drug release was non-fickian i.e.,
swelling followed by erosion mechanism.
Conclusion:
This work suggests that mucoadhesive microspheres,
an effective drug delivery system for lamivudine, c
an be prepared using
drumstick mucilage in improving the bioavailability
of the drug.
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